Iga Swiatek used an outfit change to help her reset after a poor start and beat China's Zheng Qinwen.
The confrontation comes days after the FBI executed a search warrant at former president Donald Trump's Florida estate.
The 43-year-old Bopanna and 35-year-old Ebden, who claimed two doubles titles on the ATP Tour earlier this year, will next face the unseeded British pair of Jacob Fearnley and Johannus Monday on Sunday.
World number one Carlos Alcaraz faces a potential quarter-final clash with old foe Jannik Sinner in his US Open title defence, and American Coco Gauff is on a collision course with defending champion Iga Swiatek on the women's side.
Madison Keys stunned third seed Jessica Pegula 6-1, 6-3 in an all-American clash
A crowd favourite for her creative playing style, Ons Jabeur rolls into her second straight Grand Slam championship match brimming with confidence, with lessons learned from her heartbreaking loss at the All England Club to Kazakhstan's Elena Rybakina.
The first teenager to play in a US Open final since Serena in 2001 there was symmetry to the moment as Gauff rallied to beat the second seeded Belarusian 2-6, 6-3, 6-2 and end a six-year barren stretch for American tennis fans, who were finally able to celebrate a homegrown champion.
Novak Djokovic enjoyed a stress-free return to US competition following a two year absence
Coco Gauff became the first American to win a US Open singles title since Sloane Stephens in 2017.
Need to raise game against Djokovic, says Medvedev ahead of US Open final
Bronny James, NBA legend LeBron James's 18-year-old son, suffered a cardiac arrest while practicing with the University of Southern California basketball team and was in stable condition.
Medvedev on everyone's US Open radar after first round rout
Petra Kvitova added another happy memory at the All England Lawn Tennis Club
LeBron James thanked fans on Thursday for their love and prayers for his son Bronny, who suffered a cardiac arrest while training.
The governing body of women's tennis announced a new circuit structure on Tuesday with a "pathway to handing out equal prize money" for men and women at combined WTA 1000 and 500 events.
Rafael Nadal returns to the US Open for the first time in three years short of match practice and with big question marks about his fitness but few people will dismiss the Spaniard's chances of claiming a record-extending 23rd Grand Slam title.
Fans are buzzing over the prospect of a rematch between world number one Alcaraz and second seed Djokovic in a potential New York finale
Williams has just one professional tournament remaining before she drops the curtain on her historic career
Fourth seed Agnieszka Radwanska of Poland withdrew from the Western and Southern Open for personal reasons on Thursday, sending defending champion Li Na of China through to the semi-finals.
Sinner is most likely to upset the applecart after the Italian's run to the Canadian Open title this month
After reaching the semi-finals of the women's doubles event in Toronto with Madison Keys, Sania also played at last week's Cincinnati Open.
US Open champion Carlos Alcaraz has become the youngest world number one since the ATP rankings began in 1973.
Novak Djokovic has no intention of passing the torch to the next generation just yet.
'Serena must be prepared to live with it and say goodbye even in the face of defeat'
Carlos Alcaraz ended Australian qualifier Max Purcell's dream run to reach the Cincinnati Open semi-finals
Raducanu stormed into the third round of the Cincinnati Open
IMAGES from all the action on Day 7 of the US Open played at the USTA Billie Jean King Tennis Center at Flushing Meadows in New York on Sunday.
Frances Tiafoe, Taylor Fritz, Tommy Paul and Coco Gauff all advanced to the third round of the US Open on Wednesday to keep home hopes alive.
Images from Day 3 of the US Open, at Flushing Meadows, New York.
Novak Djokovic marched into the semis of the Dubai Tennis Championship, with a comfortable win over Hubert Hurkacz.
Indian tennis star Sania Mirza and her new Czech partner Barbora Strycova have been seeded seventh at the WTA Western and Southern Open, one of the two events in tune-up to the US Open.
A summary of Thursday's action at the US Open.
Rohan Bopanna revealed that he will bring curtains down on his Davis Cup career when the country hosts Morocco in September
Images from the US Open women's semi-finals on Thursday.
The five top contenders for the women's title at the Australian Open, which starts on Monday.
Former US Open champion Svetlana Kuznetsova has joined a growing list of players who have decided not to play in this year's tournament due to concerns over the COVID-19 pandemic.
John Peers and Storm Sanders became the first Australians since 2001 to claim the US Open mixed doubles title with a 4-6, 6-4, 10-7 win over Belgian Kirsten Flipkens and France's Edouard Roger-Vasselin on Saturday.
Medvedev's deep groundstrokes have been a major component of his clay-court progression. His baseline retrieving has been the foundation of his hard-court success, and he attributed his success on the clay this year to a string change at the start of the 2023 season.
Osaka's hardcourt swing leading into the US Open has been rough
Serena Williams was included on the entry list for the US Open on Wednesday along with fellow former champion Novak Djokovic, who will not be able to compete due to his refusal to be vaccinated against COVID-19.